Casey Howshall

Oct 10, 2024 | science.org | Dimitri Fabrèges |Stephanie E. Hampton |Shawn Ng |Casey Howshall

Editor’s summaryThe prenyl group is a hydrophobic five-carbon fragment common across a wide range of contexts in biochemistry and natural product chemistry. One extensive class of natural products of pharmaceutical interest, polycyclic polyprenylated acylphloroglucinols (PPAPs), has been the target of multiple synthetic studies, but the introduction of the prenyl groups asymmetrically has proven to be an enduring challenge. Ng et al.