Cassandra N. Spracklen

1 month ago | digitalcommons.library.tmc.edu | Anubha Mahajan |Cassandra N. Spracklen |Weihua Zhang |Lauren Petty

AbstractWe assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10-9), which were delineated to 338 distinct association signals.