Cássia Campanhol Lemes

Sep 24, 2024 | analyticalsciencejournals.onlinelibrary.wiley.com | Daniel Ribeiro |Cássia Campanhol Lemes

1 INTRODUCTION Developed in the 1980s, fluorescence in situ hybridization (FISH) is a molecular cytogenetic technique that marked the beginning of a new era for studying the structure and function of chromosomes (Chrzanowska et al., 2020; Levsky & Singer, 2003). The DNA FISH technology is used to study chromosomal and genomic alterations in cell suspensions and tissue block preparations. In oncology, most biological samples are available in formalin-fixed paraffin-embedded tissues (FFPE).