Catharine A. Adams

Nov 18, 2024 | biorxiv.org | Catharine A. Adams |Candace S. Bever |Jacquelyn M. Blake-Hedges |Sean Brown

AbstractThe death cap mushroom, Amanita phalloides, is well known for containing amatoxins such as alpha- and beta-amanitin, which inhibit eukaryotic RNA polymerase II. While these toxins have been used in research for almost a century, they have recently garnered attention for their role in drug-antibody conjugates. The amatoxins are still largely extracted from wild mushrooms, which cannot be made to fruit in the lab.