Catherine Iorio

Oct 31, 2023 | cell.com | Byrne C.J |Lauren Podmore |Catherine Iorio |Kevin Nixon

Highlights•Insulin receptor (INSR) is broadly expressed in breast cancer (BC)•INSR deletion suppresses mammary tumorigenesis driven by Her2 and PyMT oncogenes•INSR affects tumor initiation, not progression and metastasis•INSR upholds bioenergetic fitness of mammary epithelial cellsSummaryBreast cancer (BC) prognosis and outcome are adversely affected by obesity. Hyperinsulinemia, common in the obese state, is associated with higher risk of death and recurrence in BC.