Chang-Yu Hsieh

Oct 8, 2023 | onlinelibrary.wiley.com | Chang-Yu Hsieh |Tsen-Fang Tsai

LETTER Ultraviolet B-induced punctate hyperkeratosis in a patient with vitiligo Chang-Yu Hsieh, Chang-Yu Hsieh Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan Search for more papers by this authorTsen-Fang Tsai, Corresponding Author Tsen-Fang Tsai Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan Correspondence Tsen-Fang Tsai, Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of...

Sep 7, 2023 | nature.com | Chao Shen |Yu Kang |Furui Liu |Guangyong Chen |Chang-Yu Hsieh |RenLing Hu

AbstractMost molecular generative models based on artificial intelligence for de novo drug design are ligand-centric and do not consider the detailed three-dimensional geometries of protein binding pockets. Pocket-aware three-dimensional molecular generation is challenging due to the need to impose physical equivariance and to evaluate protein–ligand interactions when incrementally growing partially built molecules.

Jul 4, 2023 | pubs.rsc.org | Tingjun Hou |Chao Shen |Xujun Zhang |Chang-Yu Hsieh

A generalized protein-ligand scoring framework with balanced scoring, docking, ranking and screening powers Tingjun Hou, Chao Shen, Xujun Zhang, Chang-Yu Hsieh, Yafeng Deng, Dong Wang, Lei Xu, Jian Wu, Dan Li, Yu Kang and Peichen Pan Abstract Applying machine learning algorithms to protein-ligand scoring functions has aroused widespread attention in recent years due to the high predictive accuracy and affordable computational cost. Nevertheless, most machine learning-based scoring functions...