Changin Kim

Aug 13, 2024 | nature.com | Changin Kim |Sang Lee |Seong Ok Kim |Hyosub Lee |Jungkweon Choi |Jong Kim | +4 more

AbstractThe Light-oxygen-voltage-sensing domain (LOV) superfamily, found in enzymes and signal transduction proteins, plays a crucial role in converting light signals into structural signals, mediating various biological mechanisms. While time-resolved spectroscopic studies have revealed the dynamics of the LOV-domain chromophore’s electronic structures, understanding the structural changes in the protein moiety, particularly regarding light-induced dimerization, remains challenging.

Jul 25, 2024 | nature.com | Seong Ok Kim |Hyosub Lee |Doo-Sik Ahn |Doyeong Kim |Robert Henning |Sang Lee | +2 more

AbstractUnderstanding protein structure and kinetics under physiological conditions is crucial for elucidating complex biological processes. While time-resolved (TR) techniques have advanced to track molecular actions, their practical application in biological reactions is often confined to reversible photoreactions within limited experimental parameters due to inefficient sample utilization and inflexibility of experimental setups.