Changjun Hou

Jan 6, 2025 | pubs.rsc.org | Changjun Hou

A universal two-step strategy for multiple DNA MTase activity: Enhancing sensitivity through CRISPR/Cas12a-assisted hyperbranched rolling circle amplification (CA-HRCA) DNA methyltransferase (DNA MTase) is a valuable target of genetic diseases, and detection of related DNA MTase activity is very important for drug screening, clinical diagnosis and disease treatment.

Jan 2, 2024 | sciencedirect.com | Yue Qiu |Changjun Hou |Cong Fan |Xian Chen

Cervical cancer is the fourth leading cause of cancer mortality among women and remains a major challenge for public health. In 2020, an estimated 604,000 women were diagnosed with cervical cancer worldwide, and approximately 342,000 women died from the disease (Sung et al., 2021). Screening for human papillomavirus (HPV) infection is one of the most important preventative measures because almost all cervical cancers are attributable to HPV infection (Mao et al., 2023).

Jan 2, 2024 | sciencedirect.com | Yue Qiu |Changjun Hou |Cong Fan |Xian Chen

Thalassemia, also known as Mediterranean anemia, is a widely prevalent monogenic autosomal recessive blood disorder worldwide (Chen et al., 2021; Goonasekera et al., 2018). It can be categorized into two types: α-thalassemia and β-thalassemia. α-Thalassemia is caused by the deletion or single nucleotide variations (SNVs) in the α-globin gene, leading to reduced or absent synthesis of α-globin chains (Ning et al., 2023).