Chenbo Yan

Aug 17, 2023 | biorxiv.org | Patrick McConnell |Chenbo Yan |Olivia L Mooren |Melissa D. Stuchell-Brereton

AbstractActin capping protein (CP) can be regulated by steric and allosteric mechanisms. The molecular mechanism of the allosteric regulation at a biophysical level includes linkage between the binding sites for three ligands: F-actin, Capping-Protein-Interacting (CPI) motifs, and V-1/myotrophin, based on biochemical functional studies and solvent accessibility experiments.