Chia-Heng Hsiung

Nov 28, 2024 | nature.com | Chia-Heng Hsiung |Xin Zhang

The miniaturization and redesigning of proteins to bear fluorescence signals can broaden their scope for potential applications. Now, one can construct a range of compact artificial fluorescent proteins and develop protein biosensors by genetically encoding a natural fluorescent protein chromophore analogue.

Apr 19, 2024 | onlinelibrary.wiley.com | Junbao Ma |Zhejiang Province |Feng Luo |Chia-Heng Hsiung

Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

Nov 15, 2023 | nature.com | Andrew Latham |Chia-Heng Hsiung |Yu Chi Liu |Bin Zhang

AbstractMembraneless organelles within cells have unique microenvironments that play a critical role in their functions. However, how microenvironments of biomolecular condensates affect their structure and function remains unknown. In this study, we investigated the micropolarity and microviscosity of model biomolecular condensates by fluorescence lifetime imaging coupling with environmentally sensitive fluorophores.