Chiara Marabelli

Jul 28, 2024 | nature.com | Antonio Chaves-Sanjuan |Melissa Milazzo |Giulia Mazzini |Paola Rognoni |Paolo Milani |Chiara Marabelli | +9 more

AbstractSystemic light chain (LC) amyloidosis (AL) is a disease where organs are damaged by an overload of a misfolded patient-specific antibody-derived LC, secreted by an abnormal B cell clone. The high LC concentration in the blood leads to amyloid deposition at organ sites. Indeed, cryogenic electron microscopy (cryo-EM) has revealed unique amyloid folds for heart-derived fibrils taken from different patients.