Chih-Ming Tsai

Dec 16, 2024 | jci.org | Chih-Ming Tsai |Irshad A. Hajam |J.R. Caldera |Austin Chiang |Xin Du |Emi Suzuki | +10 more

AbstractThe pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa modifies antibody activity is not clear. Herein, we demonstrate that IL-10 is the decisive factor that abrogates antibody protection in mice. Sa-induced B10 cells drive antigen-specific vaccine suppression that affects both recalled and de novo developed B cells.