Chongbin Hu

Mar 18, 2024 | prod--journal.elifesciences.org | Chongbin Hu |Nan Zhang |Yun Hong |Ruxiu Tie

eLife assessment This study characterizes the composition and immune diversity of the zebrafish kidney, the immune organ equivalent to human bone marrow, with convincing single-cell transcriptomic data of hematopoietic cells and immunocytes. The key findings suggest that zebrafish kidney is a secondary lymphatic organ, and that hematopoietic stem cells in zebrafish may exhibit trained immunity, which are the unique features of the fish immune system.

Oct 8, 2023 | biorxiv.org | Nan Zhang |Yun Hong |Ruxiu Tie |Chongbin Hu

AbstractThe vertebrate kidneys play two evolutionary conserved roles in waste excretion and osmoregulation. Besides, the kidney of fish is considered as a functional ortholog of mammalian bone marrow that serves as a hematopoietic hub for generating blood cell lineages and immunological responses. However, knowledge about the properties of kidney hematopoietic cells, and the functionality of kidney in fish immune systems remain to be elucidated.