Christian R. Baumann

Oct 24, 2024 | onlinelibrary.wiley.com | Pengfei Liu |Christian R. Baumann |Oliver Zerbe |David Streuli

1 INTRODUCTION Some metal ions are essential for life, whereas others are toxic to cells, even at low concentrations, and therefore need to be tightly regulated. Organisms, particularly gastropods, have therefore developed ways of immobilizing toxic metal ions in order to cope with variable levels of these metals in their environment (Dallinger et al., 2020).

Jul 27, 2023 | onlinelibrary.wiley.com | Christian R. Baumann |Oliver Zerbe

The role of other amino acids in hydropathy tuning Other amino acids (foremost Lys and Val) display similar albeit mostly weaker patterns as found for Leu in variances (Figure 1D) and correlations (Figure ) and thus appear to tune TMD hydropathy to some extent as well. Since tuning results in a reduction of hydropathy variation between receptors, the absolute impact of each amino acid can be measured using the change in hydropathy standard deviation (Figure 3A).