Christian Röver

1 month ago | nature.com | Stefan Anker |Javed Butler |Frank Rockhold |Christian Röver |Marius Placzek

AbstractUncertainty remains about the effect of intravenous (IV) iron on outcomes for heart failure (HF) with iron deficiency. Here, we summarize the efficacy and safety of IV iron from six trials (FAIR-HF, CONFIRM-HF, AFFIRM-AHF, IRONMAN, HEART-FID, and FAIR-HF2) including 7,175 patients. In comparison to prior analyses, this meta-analysis adds new data from FAIR-HF2, uses a harmonized and robust Bayesian approach, and includes individual participant data from 5 trials.

Sep 2, 2024 | onlinelibrary.wiley.com | Christian Röver |Tim Friede

1 Introduction In drug licensing, evidence from several independent sources is often required to demonstrate efficacy and safety of novel treatments (The European Agency for the Evaluation of Medicinal Products (EMEA) 2001; Kennedy-Shaffer 2017). Especially in health technology assessment, meta-analysis methods are commonly applied to combine and judge evidence from several sources, for example, typically a small number of clinical trials conducted in the later development phases (Bender et al.