Christine M. Kusminski

Jan 7, 2025 | cell.com | Xinxin Yu |Shiuhwei Chen |Jan-Bernd Funcke |Leon G. Straub |Valentina Pirro |Margo P. Emont | +15 more

KeywordsGIP receptoradipose tissueobesityweight lossenergy expenditureSERCA pathwayIntroductionThe prevalence of obesity has substantially increased. The World Health Organization recognizes obesity as a worldwide epidemic and a major disease of the 21st century, with >4 million people dying in 2017.1 Obesity is characterized as excessive fat accumulation that presents a health risk, which results from a dysregulation in energy homeostasis, i.e., caloric intake exceeding energy expenditure.

Jul 25, 2024 | cell.com | Christine M. Kusminski |Diego Perez-Tilve |Richard D. DiMarchi |Matthias H. Tschöp

Dale C.E. Fatemifar G. Palmer T.M. White J. Prieto-Merino D. Zabaneh D. Engmann J.E.L. Shah T. Wong A. Warren H.R. et al. Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. Circulation. 2017; 135: 2373-2388https://doi.org/10.1161/CIRCULATIONAHA.116.026560Islami F. Goding Sauer A. Gapstur S.M. Jemal A. Proportion of Cancer Cases Attributable to Excess Body Weight by US State, 2011-2015.