Christopher R. Gignoux

May 10, 2024 | biorxiv.org | Cole Williams |Jared O’Connell |William A. Freyman |Christopher R. Gignoux

ABSTRACTHaplotype phasing, the process of determining which genetic variants are physically located on the same chromosome, is crucial for various genetic analyses. In this study, we first benchmark SHAPEIT and Beagle, two state-of-the-art phasing methods, on two large datasets: > 8 million diverse, research-consented 23andMe, Inc. customers and the UK Biobank (UKB). We find that both perform exceptionally well.

Mar 22, 2023 | jacionline.org | Katie M. Marker |Rasika A. Mathias |Johns Hopkins |Christopher R. Gignoux

Eosinophilic esophagitis (EoE), a chronic allergic inflammatory disease, is linked to multiple genetic risk factors, but studies have focused on populations of European ancestry. Few studies have assessed Black or African American (AA) populations for loci involved in EoE susceptibility.