Christopher S. Stach

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High-throughput investigation of genetic design constraints in domesticated Influenza A Virus for transient gene delivery

Feb 15, 2024 | biorxiv.org | Adam Sychla |Christopher S. Stach |Amanda Hayward |Shanley Roach

AbstractReplication-incompetent single cycle infectious Influenza A Virus (sciIAV) has demonstrated utility as a research and vaccination platform. Protein-based therapeutics are increasingly attractive due to their high selectivity and potent efficacy but still suffer from low bioavailability and high manufacturing cost.

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