Chu Wang

Jan 3, 2025 | pubs.rsc.org | Chu Wang

Chemical proteomic profiling of lysine crotonylation by minimalist bioorthogonal probes in mammalian cells Protein lysine crotonylation has been found to be closely related to the occurrence and development of various diseases. Currently, site identification of crotonylation is mainly dependent on antibody enrichment, however, due to the cost, heterogeneity, and specificity of antibodies, it is desired to develop an alternative chemical tool to detect crotonylation.

Oct 25, 2024 | mdpi.com | Yiming Wu |Kai Zhu |Chu Wang |YUE LI

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Sep 12, 2024 | onlinelibrary.wiley.com | Jing Qi |Chu Wang |Gan Wang |Patrick O’Neill

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May 7, 2024 | nature.com | Chenguang Zhang |Chu Wang

AbstractNeuronal ferroptosis plays a key role in neurologic deficits post intracerebral hemorrhage (ICH). However, the endogenous regulation of rescuing ferroptotic neurons is largely unexplored. Here, we analyzed the integrated alteration of metabolomic landscape after ICH using LC-MS and MALDI-TOF/TOF MS, and demonstrated that aconitate decarboxylase 1 (Irg1) and its product itaconate, a derivative of the tricarboxylic acid cycle, were protectively upregulated.

Mar 20, 2023 | nature.com | Chu Wang

AbstractLow-carbon city construction is one of the key issues that must be addressed for China to achieve high-quality economic development and meet the Sustainable Development Goals. This study creates a comprehensive evaluation index system of low-carbon city multivariate system based on carbon emission data from 30 typical Chinese cities from 2006 to 2017 and evaluates and analyzes the trend of city low-carbon levels using the CRITIC-TOPSIS technique and MK method.