Chuling Zhuang

Oct 12, 2024 | mdpi.com | Mariana K. Najjar |Munazza Khan |Chuling Zhuang |Ankush Chandra

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May 20, 2024 | jbc.org | Altman Clinical |Chuling Zhuang

ABSTRACTProtein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is encoded by a major autoimmunity gene and is a known inhibitor of T cell receptor (TCR) signaling and drug target for cancer immunotherapy. However, little is known about PTPN22 post-translational regulation. Here we characterize a phosphorylation site at Ser325 situated C-terminal to the catalytic domain of PTPN22, and its roles in altering protein function.