Chun-Hsiung Wang

Sep 15, 2023 | nature.com | Kuan-Jen Lu |Chiung-Wen Chang |Chun-Hsiung Wang |Frederic Y-H Chen |Irene Huang |Cheng-Han Yang | +4 more

Correction to: Nature Metabolism https://doi.org/10.1038/s42255-023-00831-w, published online 22, June 2023. In the version of this article originally published, panels b–k of Figure 6 were inadvertently mislabeled. Aside from the panel labels, the figure has not been changed, and the descriptions in the text and the legend are not affected. The errors have been corrected in the HTML and PDF versions of the article.

Jun 22, 2023 | nature.com | Kuan-Jen Lu |Chiung-Wen Chang |Chun-Hsiung Wang |Irene Huang |Cheng-Han Yang |Wen-Jin Wu | +4 more

AbstractRegulation of CO2 fixation in cyanobacteria is important both for the organism and global carbon balance. Here we show that phosphoketolase in Synechococcus elongatus PCC7942 (SeXPK) possesses a distinct ATP-sensing mechanism, where a drop in ATP level allows SeXPK to divert precursors of the RuBisCO substrate away from the Calvin–Benson–Bassham cycle. Deleting the SeXPK gene increased CO2 fixation particularly during light–dark transitions.

May 22, 2023 | nature.com | Meng-Chiao Ho |Chun-Hsiung Wang

AbstractHuman mitochondrial NAD(P)+-dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involved in cancer or epilepsy. We present potent ME2 inhibitors based on cyro-EM structures that target ME2 enzyme activity. Two structures of ME2-inhibitor complexes demonstrate that 5,5’-Methylenedisalicylic acid (MDSA) and embonic acid (EA) bind allosterically to ME2’s fumarate-binding site.