Chun Mao

Oct 21, 2024 | onlinelibrary.wiley.com | Lulu Wang |Yao Zhang |Chun Mao |Xiaoqiang Li

1 Introduction Abdominal aortic aneurysm (AAA) is a common cardiovascular condition characterized by abnormal dilation of the abdominal aorta.[1] It is highly prevalent and hazardous,[2] and large AAAs often require surgical intervention.

Jul 23, 2024 | nature.com | Wentao Jiang |Jian Shen |Chun Mao |Min Zhou

Correction to: Nature Nanotechnology https://doi.org/10.1038/s41565-024-01681-7, published online 27 May 2024. In the version of this article originally published online, in the color key to Fig. 4h, “7. CM/NM/Mito i.v. (5 times)” should have been “7. CM/NM/Mito@Cap (5 times)”, and “8. CM/NM/Mito@Cap (5 times)” should have been “8. CM/NM/Mito i.v. (5 times)”.

May 27, 2024 | nature.com | Wentao Jiang |Jian Shen |Chun Mao |Min Zhou

AbstractMitochondrial transplantation is an important therapeutic strategy for restoring energy supply in patients with ischaemic heart disease (IHD); however, it is limited by the invasiveness of the transplantation method and loss of mitochondrial activity. Here we report successful mitochondrial transplantation by oral administration for IHD therapy.

Jan 12, 2024 | pubs.rsc.org | Lin Chen |Wenyan Guo |Chun Mao |Jian Shen

Liver fibrosis: pathological features, clinical treatment and application of therapeutic nanoagents Liver fibrosis is a reversible damage-repair response, whose pathological features mainly include damage of hepatocytes, sinusoid capillarization, hepatic stellate cells (HSCs) activation, excessive accumulation of extracellular matrix (ECM) and inflammatory response.

Feb 20, 2023 | nature.com | Chun Mao |Jian Shen

AbstractThe major challenges of immunotherapy for glioblastoma are that drugs cannot target tumor sites accurately and properly activate complex immune responses. Herein, we design and prepare a kind of chemotactic nanomotor loaded with brain endothelial cell targeting agent angiopep-2 and anti-tumor drug (Lonidamine modified with mitochondrial targeting agent triphenylphosphine, TLND).