Claudia Cicognola

Jul 3, 2023 | n.neurology.org | Claudia Cicognola |Niklas Mattsson-Carlgren |Danielle van Westen |Henrik Zetterberg

AbstractBackground and Objectives Injured pericytes in the neurovascular unit release platelet-derived growth factor β (PDGFRβ) into the CSF. However, it is not clear how pericyte injury contributes to Alzheimer disease (AD)–related changes and blood-brain barrier (BBB) damage. We aimed to test whether CSF PDGFRβ was associated with different AD-associated and age-associated pathologic changes leading to dementia.