Clayton M. Dilks

Jan 14, 2025 | journals.plos.org | J. B. Collins |Johns Hopkins |Clayton M. Dilks |Molecular Biosciences |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Collins JB, Dilks CM, Hahnel SR, Rodriguez B, Fox BW, Redman E, et al. (2025) Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin. PLoS Pathog 21(1): e1012602. https://doi.org/10.1371/journal.ppat.1012602Editor: Adler R.

Sep 24, 2024 | biorxiv.org | JB Collins |Clayton M. Dilks |Briana Rodriguez |Steffen R. Hahnel

AbstractWidespread anthelmintic resistance has complicated the management of parasitic nematodes. Resistance to the benzimidazole (BZ) drug class is nearly ubiquitous in many species and is associated with mutations in beta-tubulin genes. However, mutations in beta-tubulin alone do not fully explain all BZ resistance.