Clermont Auvergne

Apr 24, 2024 | academic.oup.com | CHU Clermont-Ferrand |Clermont Auvergne

Despite the use of validated guidelines in the management of mild traumatic brain injury (mTBI), processes to limit unnecessary brain scans are still not sufficient and need to be improved. The use of blood biomarkers represents a relevant adjunct to identify patients at risk for intracranial injury requiring computed tomography (CT) scan. Biomarkers currently recommended in the management of mTBI in adults and children are discussed in this review.

Feb 28, 2024 | academic.oup.com | Clermont Auvergne

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis in advanced stages. While therapies targeting the checkpoint molecules programmed cell death 1 (PD-1), its ligand PD-L1 and the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) have revolutionized treatment in many cancers, the results in ACC were heterogeneous. Their expression in ACC has not been systematically studied and might explain the variable response to checkpoint inhibitors.

Dec 27, 2023 | academic.oup.com | Clermont Auvergne

This paper relates curiosity to economic development through its impact on human capital formation and technological advancement in pre-modern times. More specifically, we propose that exposure to inexplicable phenomena prompts curiosity and thinking in an attempt to comprehend these mysteries, thus raising human capital and technology, and, ultimately, fostering growth.

Sep 29, 2023 | link.aps.org | Clermont Auvergne |Dimitrios Karamitros |Ioannis Dalianis |Andreas Goudelis

The freeze-in mechanism has been shown to allow the simultaneous generation of cosmic dark matter and a viable matter-antimatter asymmetry in the Universe. When the underlying interactions are described by higher-dimensional, nonrenormalizable operators, the relevant freeze-in processes take place close to the highest considered cosmic temperatures.