Clint Vorauer

Apr 30, 2024 | biorxiv.org | Michael J Rudolph |Yang Chen |David Vance |Clint Vorauer

AbstractLyme disease is a tick-borne, multisystem infection caused by the spirochete, Borreliella burgdorferi. Although antibodies have been implicated in the resolution of Lyme disease, the specific B cell epitopes targeted during human infections remain largely unknown. In this study, we characterized and defined the structural epitope of a patient-derived bactericidal monoclonal IgG (B11) against Outer surface protein C (OspC), a homodimeric lipoprotein necessary for B.