Cody Whitley

Nov 23, 2024 | mdpi.com | Rakshya Shrestha |Paige Johnson |Roshan Ghimire |Cody Whitley

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

May 25, 2024 | biorxiv.org | Rakshya Shrestha |Paige Johnson |Roshan Ghimire |Cody Whitley

AbstractRNA virus induced excessive inflammation and impaired antiviral interferon (IFN-I) responses are associated with severe disease. This innate immune response, also referred to as dysregulated immunity, is caused by viral single-stranded RNA (ssRNA) and double-stranded-RNA (dsRNA) mediated exuberant inflammation and viral protein-induced IFN antagonism. However, key host factors and the underlying mechanism driving viral RNA-mediated dysregulated immunity are poorly defined.