Conggang Li

Dec 18, 2024 | pubs.rsc.org | Conggang Li

Aromatic-Aromatic Interactions Drive Fold Switch of GA95 and GB95 with Three Residue Difference Proteins typically adopt a single fold to carry out their function, but metamorphic proteins, with multiple folding states, defy this norm. Deciphering the mechanism of conformational interconversion of metamorphic proteins is challenging.

Jul 5, 2024 | chemistry-europe.onlinelibrary.wiley.com | Shixia Ji |Conggang Li |Maili Liu |Yixiang Liu

Two-component signal transduction systems (TCSs) are regulatory systems widely distributed in eubacteria, archaea, and a few eukaryotic organisms, but not in mammalian cells. A typical TCS consists of a histidine kinase and a response regulator protein. Functional and mechanistic studies on different TCSs have greatly advanced the understanding of cellular phosphotransfer signal transduction mechanisms.