Connor Hagen

3 weeks ago | tandfonline.com | Timothy Paradis |Qing Zhang |Laurie Tylaska |Connor Hagen

ABSTRACTAims To determine whether using a pH-sensitive peptide (CBX-15) for antigen-independent targeting of MMAE to tumors induced anti-tumor efficacy via direct and immunological mechanisms in the rat tumor model. Methods CBX-15 was assessed for its ability to kill tumor cells and induce immunogenic cell death (ICD) in female Fischer rats bearing syngeneic 13762 mammary adenocarcinoma tumors via in vivo and ex vivo functional assays.