Coraline Borowczyk

Jan 1, 2025 | nature.com | Coraline Borowczyk

AbstractAtherosclerotic cardiovascular diseases are the most frequent cause of death worldwide. The clinical complications of atherosclerosis are closely linked to the haematopoietic and immune systems, which maintain homeostatic functions and vital processes in the body. The nodes linking metabolism and inflammation are receiving increasing attention because they are inextricably linked to inflammatory manifestations of non-communicable diseases, including atherosclerosis.

Nov 18, 2024 | nature.com | Coraline Borowczyk |Minna Kaikkonen |William Tressel |James B. Stein |Edward B Thorp |Emmanuel L. Gautier | +3 more

AbstractMetabolic dysregulation, including perturbed glutamine–glutamate homeostasis, is common among patients with cardiovascular diseases, but the underlying mechanisms remain largely unknown. Using the human MESA cohort, here we show that plasma glutamine–glutamate ratio is an independent risk factor for carotid plaque progression.