Cristina Marta Del-Ben

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The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis | Translational Psychiatry

Oct 25, 2024 | nature.com | Luis Alameda |Marta Di Forti |Celso Arango |Miguel Bernardo |Julio Bobes |Cristina Marta Del-Ben | +11 more

AbstractChildhood adversity is associated with various clinical dimensions in psychosis; however, how genetic vulnerability shapes the adversity-associated psychopathological signature is yet to be studied.
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study | Molecular Psychiatry

Apr 16, 2023 | nature.com | Luis Alameda |Zhonghua Liu |Celso Arango |Miguel Bernardo |Julio Bobes |Peter Jones | +14 more

AbtractStudies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome wide association studies (EWAS) using the Illumina Infinium-Methylation EPIC array in peripheral blood tissue from 366 First-episode of psychosis and 517 healthy controls was performed.

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