Critical Disorders

Oct 28, 2024 | journals.plos.org | Maoxian Li |Critical Disorders |Chengdu Women’s |Sichuan province

Loading metrics Open Access Peer-reviewedResearch Article Citation: Li M, Liu J, Jin L, Mi T, Zhang Z, Zhanghuang C, et al. (2024) ZSTK474 targeting PIK3R3 inhibits the Wilms’ tumor through G0 / G1 phase arrest. PLoS ONE 19(10): e0312178. https://doi.org/10.1371/journal.pone.0312178Editor: Amarinder Singh, The University of Tennessee Health Science, UNITED STATES OF AMERICAReceived: July 5, 2024; Accepted: October 2, 2024; Published: October 28, 2024Copyright: © 2024 Li et al.

Apr 24, 2024 | respiratory-research.biomedcentral.com | Critical Disorders

BMDCs were obtained from mouse femurs and tibiae according to previously described methods [17]. T cells were obtained from the spleens of C57BL/6 mice using the Mouse Spleen Lymphocyte Isolation Kit (Hao Yang Bio, Tianjin, China) according to the manufacturer’s instructions.

Apr 16, 2024 | bmcpediatr.biomedcentral.com | Critical Disorders

ReferencesDong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 among children in China[J]. Pediatrics. 2020;145(6). https://doi.org/10.1542/peds.2020-0702Tian D, Sun Y, Xu H, et al. The emergence and epidemic characteristics of the highly mutated SARS-CoV-2 Omicron variant[J]. J Med Virol. 2022;94(6):2376–83. https://doi.org/10.1002/jmv.27643Article  CAS  PubMed  PubMed Central  Google Scholar  Pascarella A, Maglione M, Lenta S, et al.

Oct 27, 2023 | cardiab.biomedcentral.com | Critical Disorders

Male C57BL/6 mice were obtained from Beijing HFK Biologic Technology (Beijing, China), while transgenic mice overexpressing Klotho were obtained from Cyagen Biosciences (Suzhou, China). The TgKL mice were generated by microinjecting a fusion gene consisting of the EF1α promoter and soluble form of mouse sKL cDNA (TgKL, pRP [Exp]-EF1A > KL [AB010088.1]) into fertilized mouse eggs from C57BL/6 females mated with C57BL/6 males.

Jul 15, 2023 | link.springer.com | Critical Disorders

AbstractFocal segmental glomerulosclerosis (FSGS) is a leading cause of steroid-resistant nephrotic syndrome (SRNS) that predominantly affects the podocytes. While mutations in genes causing pediatric SRNS have enhanced our understanding of FSGS, the disease’s etiology remains complex and poorly understood. Whole exome sequencing (WES) was performed on a 9-year-old girl with SRNS associated with FSGS (SRNS–FSGS).