Cynthia Schofield

Oct 13, 2024 | nature.com | Daniel Gibson |Ayano Matsushima |Cynthia Schofield |Patlapa Sompolpong |Kathy Tran |Lin Tian

AbstractWe recorded dopamine release signals in centromedial and centrolateral sectors of the striatum as mice learned consecutive versions of visual cue-outcome conditioning tasks. Dopamine release responses differed for the centromedial and centrolateral sites. In neither sector could these be accounted for by classic reinforcement learning alone as classically applied to the activity of nigral dopamine-containing neurons.

Aug 17, 2023 | biorxiv.org | Min Jung Kim |Daniel Gibson |Dan Hu |Cynthia Schofield

AbstractWe recorded dopamine release signals in medial and lateral sectors of the striatum as mice learned consecutive visual cue-outcome conditioning tasks including cue association, cue discrimination, reversal, and probabilistic discrimination task versions. Dopamine release responses in medial and lateral sites exhibited learning-related changes within and across phases of acquisition. These were different for the medial and lateral sites.