Cyril Planchais

Aug 21, 2024 | biorxiv.org | Delphine Planas |Isabelle Staropoli |Cyril Planchais |Emilie Yab

AbstractFirst-generation anti-SARS-CoV-2 monoclonal antibodies (mAbs) used for prophylaxis or therapeutic purposes in immunocompromised patients have been withdrawn because of the emergence of resistant Omicron variants. In 2024, two novel mAbs, Pemivibart and Sipavibart, have been approved by health authorities, but their activity against contemporary JN.1 sublineages is poorly characterized.

Jul 12, 2024 | nature.com | Nia Toshkova |Violeta Zhelyzkova |Alejandra Reyes-Ruiz |Maxime Lecerf |Nolwenn Jouvenet |Cyril Planchais

AbstractThe bat immune system features multiple unique properties such as dampened inflammatory responses and increased tissue protection, explaining their long lifespan and tolerance to viral infections. Here, we demonstrated that body temperature fluctuations corresponding to different physiological states in bats exert a large impact on their antibody repertoires.

Jan 10, 2024 | nature.com | Caroline Passaes |Delphine Desjardins |Valérie Monceaux |Federico Perdomo-Celis |Cyril Planchais |Nathalie Dereuddre-Bosquet | +10 more

AbstractHIV remission can be achieved in some people, called post-treatment HIV controllers, after antiretroviral treatment discontinuation. Treatment initiation close to the time of infection was suggested to favor post-treatment control, but the circumstances and mechanisms leading to this outcome remain unclear. Here we evaluate the impact of early (week 4) vs.

Oct 25, 2023 | nature.com | Nell Saunders |Cyril Planchais |Vincent Michel |Françoise Porrot |Catherine Blanc |Déborah Delaune | +4 more

AbstractFour endemic seasonal human coronaviruses causing common colds, HKU1, 229E, NL63 and OC43 circulate worldwide1. After binding to cellular receptors, coronavirus spike proteins are primed for fusion by transmembrane-serine protease 2 (TMPRSS2) or endosomal cathepsins2-9. NL63 uses angiotensin-converting enzyme 2 (ACE2) as a receptor10, whereas 229E uses human aminopeptidase-N11. HKU1 and OC43 spikes bind cells through 9-O40 acelytated sialic acid but their protein receptors remain unknown12.