Cyrus Zhou

Mar 18, 2024 | nature.com | Hao-Wei Chang |Cyrus Zhou |Kali M. Pruss |Clara Kao |Matthew C. Hibberd |Hannah Lynn | +12 more

AbstractMicrobiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, improved weight gain in malnourished Bangladeshi children compared to a more calorically dense standard nutritional intervention.

Dec 20, 2023 | biorxiv.org | Hao-Wei Chang |Evan Lee |Yi Wang |Cyrus Zhou

AbstractPreclinical and clinical studies are providing evidence that the healthy growth of infants and children reflects, in part, healthy development of their gut microbiomes1-5. This process of microbial community assembly and functional maturation is perturbed in children with acute malnutrition.

Dec 13, 2023 | nature.com | Matthew C. Hibberd |Daniel Webber |Cyrus Zhou |Hannah Lynn |Hao-Wei Chang |Aleksandr A. Arzamasov | +6 more

AbstractEvidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition1,2,3,4. Here we analyse biospecimens from a randomized, controlled trial of a microbiome-directed complementary food (MDCF-2) that produced superior rates of weight gain compared with a calorically more dense conventional ready-to-use supplementary food in 12–18-month-old Bangladeshi children with moderate acute malnutrition4.