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A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice - Journal of Experimental & Clinical Cancer Research

Nov 4, 2024 | link.springer.com | De Angelis |Maria Laura |Anna Maria |Cytometry Unit

AbstractPrevention and treatment of metastatic breast cancer (BC) is an unmet clinical need. The retinoic acid derivative fenretinide (FeR) was previously evaluated in Phase I-III clinical trials but, despite its excellent tolerability and antitumor activity in preclinical models, showed limited therapeutic efficacy due to poor bioavailability.

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