Damon Wong

Dec 23, 2024 | alzres.biomedcentral.com | Damon Wong |Bingyao Tan |Gerhard Garhöfer |Saima Hilal |Eddie Chong |Narayanaswamy Venketasubramanian | +5 more

Our 5-year prospective study investigated the association between retinal thickness measured by OCT and the risk of cognitive decline in a large Asian cohort of 490 individuals. Thinner baseline GCIPL thickness, particularly in the superior and superior nasal regions of the macula, was significantly associated with an increased risk of cognitive decline over five years. In contrast, macular and peripapillary RNFL thickness measurements were not associated with cognitive decline.

Aug 2, 2024 | nature.com | Janika Shah |Bingyao Tan |Damon Wong |Xinyu Liu |Jacqueline Chua |Qinglan Hu | +1 more

The effect of diabetes mellitus (DM) on individual retinal layers remains incompletely understood. We evaluated the intra-retinal layer thickness alterations in 71 DM eyes with no diabetic retinopathy (DR), 90 with mild DR, and 63 with moderate DR without macular edema, using spectral-domain optical coherence tomography (SD-OCT) and the Iowa Reference Algorithm for automated retinal layer segmentation. The average thickness of 10 intra-retinal layers was then corrected for ocular magnification using axial length measurements, and pairwise comparisons were made using multivariable linear regression models adjusted for gender and race. In DM no DR eyes, significant thinning was evident in the ganglion cell layer (GCL; p < 0.001), inner nuclear layer (INL; p = 0.001), and retinal pigment epithelium (RPE; p = 0.014) compared to normal eyes. Additionally, mild DR eyes exhibited a thinner inner plexiform layer (IPL; p = 0.008) than DM no DR eyes. Conversely, moderate DR eyes displayed thickening in the INL, outer nuclear layer, IPL, and retinal nerve fiber layer (all p ≤ 0.002), with notably worse vision. These findings highlight distinctive patterns: early diabetic eyes experience thinning in specific retinal layers, while moderate DR eyes exhibit thickening of certain layers and slightly compromised visual acuity, despite the absence of macular edema. Understanding these structural changes is crucial for comprehending diabetic eye complications.

Dec 12, 2023 | nyaspubs.onlinelibrary.wiley.com | Jacqueline Chua |Damon Wong |Bingyao Tan |Xinyu Liu

INTRODUCTION Diabetes mellitus (DM)1 and hypertension (HTN)2 are prevalent chronic conditions with significant implications for retinal health.3 Several studies have used the optical coherence tomography (OCT)-derived retinal nerve fiber layer (RNFL) thickness measurement as a vital indicator of neurodegenerative changes associated with these conditions.4 Conventional OCT systems face challenges in accurately assessing RNFL measurements due to blood vessels within the RNFL, making it...

Nov 2, 2023 | europe.ophthalmologytimes.com | Lynda Charters |Damon Wong

Machine learning (ML) seems to be the wave of the future in medicine and, when perfected, it will be a most valuable diagnostic asset. However, right now the technology is in its infancy and the kinks have to be worked out and diagnostic capabilities perfected.