Daniel Chubb

1 month ago | jdsupra.com | Denise Bright |Daniel Chubb |Luke Stretch

[co-author: Kendall Pearce - Articling Student]In Flowers v Persist Oil and Gas Inc., 2025 ABKB 142,1 the Court of King's Bench of Alberta provides some important reminders to commercial landlords, tenants and their respective lenders regarding the growing intersection between real estate and the digital economy.

May 28, 2024 | nature.com | Daniel Chubb |Andrew Everall |Robert Bentham |Charlie Mills |Ben Kinnersley |Alex J. Cornish | +3 more

Interval breast cancers (IBCs) are cancers diagnosed between screening episodes. Understanding the biological differences between IBCs and screen-detected breast-cancers (SDBCs) has the potential to improve mammographic screening and patient management. We analysed and compared the genomic landscape of 288 IBCs and 473 SDBCs by whole genome sequencing of paired tumour-normal patient samples collected as part of the UK 100,000 Genomes Project. Compared to SDBCs, IBCs were more likely to be lobular, higher grade, and triple negative. A more aggressive clinical phenotype was reflected in IBCs displaying features of genomic instability including a higher mutation rate and number of chromosomal structural abnormalities, defective homologous recombination and TP53 mutations. We did not however, find evidence to indicate that IBCs are associated with a significantly different immune response. While IBCs do not represent a unique molecular class of invasive breast cancer they exhibit a more aggressive phenotype, which is likely to be a consequence of the timing of tumour initiation. This information is relevant both with respect to treatment as well as informing the screening interval for mammography.

Aug 2, 2023 | bennettjones.com | Daniel Chubb

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Jun 4, 2023 | onlinelibrary.wiley.com | Bruce Wilkie |Daniel Chubb |Bruce Wilkie MBBS

No abstract is available for this article. References 1, , , , , . Intestinal obstruction by Giant Meckel's diverticulum. GE Port. J. Gastroenterol. 2017; 24: 183– 7. 2, . Meckel's diverticulum: clinical features, diagnosis and management. Rev. Esp. Enferm. Dig. 2018; 110: 726– 32. 3, , et al. Phytobezoar impaction in a Meckel's diverticulum; a rare cause of bowel obstruction: case report and review of literature. Int. J. Surg. Case Rep. 2017; 30: 165– 8. 4, , .