Daniel Gamu

Jan 14, 2024 | biorxiv.org | Ji Soo Yoon |Daniel Gamu |William Gibson |Francis C. Lynn

AbstractRationale: Obesity is characterized by impaired energy balance and altered function of cell types that regulate food intake. These cell types include POMC neurons in the arcuate nucleus (ARC) of the hypothalamus that detect peripheral signals and promote a reduction in food intake upon activation. Downstream of neuronal activation, activity-regulated genes such as Neuronal PAS domain protein 4 (Npas4) are induced as part of the response to environmental stimuli.