Daniel J. Merk

Jun 3, 2024 | mdpi.com | Daniel J. Merk |Thomas Koenig |Janine Fritz |Joerg W. H

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Mar 31, 2023 | pubs.rsc.org | Daniel J. Merk |Laura Isigkeit

Opportunities and challenges in targeting orphan nuclear receptors Laura Isigkeit a  and  Daniel Merk *ab   Abstract Nuclear receptor modulation enables pharmacological control of gene expression thus rendering the 48 human nuclear receptors as attractive targets for drug discovery. Several nuclear receptor ligands like glucocorticoids are approved and highly important drugs illustrating the therapeutic potential of nuclear receptor modulation.

Mar 9, 2023 | mdpi.com | Thomas Koenig |Daniel J. Merk |Janine Fritz |Joerg W. H

2.2. Surface Analysis TechniquesAfter the Schaeffler FE8-25/32 test runs, the tribo-films generated on the raceway side of the tested cylindrical roller thrust bearings were characterized using the two spatially resolved spectroscopic analysis methods µXRF and ATR FTIR microscopy to determine the actual respective chemical composition of the generated tribo-films. Both methods are non-destructive, so it was possible to analyze the entire washer without any mechanical sample preparation.