Daniel Knappe

1 month ago | biorxiv.org | Daniel Knappe |Eric Reynolds |Ralf Hoffmann |Namfon Pantarat

AbstractThe rise in antibiotic resistance has meant that there is a need for new strategies and one avenue is the use of proline-rich antimicrobial peptides (PrAMPs). Here we investigate how different metal ion environments (Na+, Mg2+, Ca2+) affect antimicrobial activity of PrAMPs derived from apidaecin 1b (Api88, Api137) and Oncopeltus antibacterial peptide 4 (Onc72, Onc112) against Pseudomonas aeruginosa and Escherichia coli.