Daniel Reisenbüchler

Aug 30, 2023 | cell.com | Sophia Wagner |Daniel Reisenbüchler |Nicholas West |Jan Moritz Niehues

Highlights•AI-based prediction of biomarkers (MSI, BRAF, and KRAS) using transformers•MSI prediction reaches clinical-grade performance on biopsies of colorectal cancer•Transformer-based biomarker prediction generalizes better and is more data efficient•Large-scale multi-cohort evaluation on over 13,000 patients from 16 cohortsSummaryDeep learning (DL) can accelerate the prediction of prognostic biomarkers from routine pathology slides in colorectal cancer (CRC).