Daniel Shaw

Nov 29, 2024 | biorxiv.org | Daniel Shaw |Alexis Lambert |Michael White |Wynter D Ross

AbstractSex chromosomes often evolve unique patterns of gene expression in spermatogenesis. In many species, sex-linked genes are downregulated during meiosis in response to asynapsis of the heterogametic sex chromosome pair (meiotic sex chromosome inactivation; MSCI). Our understanding of this process has been limited to a handful of species, including mammals, Drosophila, and C. elegans. Based on findings from these taxa, MSCI has been viewed as likely a conserved process.

Aug 11, 2023 | biorxiv.org | Daniel Shaw |Michael White |Alice Shanfelter Naftaly

AbstractAllele-specific gene expression evolves rapidly on heteromorphic sex chromosomes. Over time, the accumulation of mutations on the Y chromosome leads to widespread loss of gametolog expression, relative to the X chromosome.