Daniel Zamith-Miranda

Jan 1, 2024 | nature.com | Nida Khan |Daniel Zamith-Miranda |Robert Zarnowski |Lauren J. Richey |Kenta Mosallanejad |Arianne J. Crossen | +6 more

AbstractThe host type I interferon (IFN) pathway is a major signature of inflammation induced by the human fungal pathogen, Candida albicans. However, the molecular mechanism for activating this pathway in the host defence against C. albicans remains unknown. Here we reveal that mice lacking cyclic GMP–AMP synthase (cGAS)–stimulator of IFN genes (STING) pathway components had improved survival following an intravenous challenge by C. albicans. Biofilm-associated C.