Daniela Costa

4 weeks ago | biorxiv.org | Daniela Costa |Stuart Hughes |Robert Jenkins |Ana Cardus Figueras

AbstractBackground:Rheumatoid arthritis (RA) is associated with significantly higher thrombotic risk, which is not yet mechanistically understood. Here, the role of pro-coagulant membranes of platelets and blood cells in driving thrombosis, and their regulation by inflammation was determined using human cohorts and genetically-modified mice. Methods:Antigen-induced arthritis (AIA) was induced in WT, Il27ra-/-, Il6ra-/-, Alox12-/- and Alox15-/- mice.