Daniella Pretorius

Sep 7, 2024 | biorxiv.org | Daniella Pretorius |James Murray

AbstractMotivation: Tandem repeat proteins consist of repetitive sequence and structure motifs and have diverse roles in Nature for molecular recognition and signalling. The architecture of repeat proteins can be described using simple helical parameters. Understanding these structural features can inform both the function of these proteins and be used to parametrically design new proteins. Despite their importance, no existing program is capable of completely parameterising repeat proteins.

Jul 23, 2024 | biorxiv.org | James Murray |Georgi Ivanov Nikov |Daniella Pretorius

AbstractSolenoid proteins are a subset of tandem repeat proteins, which are structurally distinct from globular proteins. Solenoid proteins are defined by their modular, elongated structures, dependent on interactions between adjacent repeats. These proteins are found across all domains of life and have many important functions such as protein binding, enzymatic catalysis, ice binding and nucleic acid binding.