Danielle Rasooly

2 months ago | nature.com | Danielle Rasooly |Claudia Giambartolomei |Gina M. Peloso |Maik Pietzner |Eric Farber-Eger |Lawrence Phillips | +4 more

AbstractHeart failure (HF) has limited therapeutic options. In this study, we differentiated the pathophysiological underpinnings of the HF subtypes—HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF)—and uncovered subtype-specific therapeutic strategies. We investigated the causal roles of the human proteome and transcriptome using Mendelian randomization on more than 420,000 participants from the Million Veteran Program (27,799 HFrEF and 27,579 HFpEF cases).

Mar 24, 2024 | medrxiv.org | Danielle Rasooly |Claudia Giambartolomei |Gina M. Peloso |Hesam Dashti

The authors have declared no competing interest. This research is based on data from the Million Veteran Program at the Office of Research and Development at the Veterans Health Administration and this work was supported by awards #MVP037 [BLR&D Merit Award BX005831] and Veterans Affairs Grant I01CX001922 (PI: Joseph) and #MVP001 [I01-BX004821]. This publication does not represent the views of the Department of Veterans Affairs or the United States Government.