Daoyuan Dong

Aug 6, 2024 | science.org | Naoto Watamura |Daoyuan Dong |Leslie K. Ferrarelli

AbstractSleep deprivation promotes tumor growth through loss of daily rhythms in cellular lipid metabolism. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Chronic sleep deprivation contributes to a slew of health problems, including the onset and progression of cancer. Peng et al.

Aug 6, 2024 | science.org | Naoto Watamura |Daoyuan Dong |Leslie K. Ferrarelli |Naomasa Kakiya

Editor’s summaryThe accumulation of amyloid-β in the brain is associated with progressive cognitive impairment in Alzheimer’s disease. Watamura et al. found that a treatment commonly used to treat a symptom of Parkinson’s disease also induced the breakdown of amyloid-β. In mice, dopamine release in the brain increased the abundance and activity of the enzyme neprilysin, which degraded amyloid-β specifically in the working memory center of the brain.

Aug 6, 2024 | science.org | Naoto Watamura |Daoyuan Dong |Leslie K. Ferrarelli |Zhe Zhang

Editor’s summaryRepeat expansions in the gene C9ORF72 frequently cause the neurodegenerative diseases ALS and frontotemporal dementia. Using neurons derived from patients, Dong et al. found that repeats of glycine-arginine (poly-GR) encoded by mutant C9ORF72 RNA stalled the translational machinery, which caused ribosomes to collide. The resulting ribotoxic stress response induced neuronal death.