David Armistead

1 month ago | biorxiv.org | Paige Allen |David Armistead |Jason A. Carlyon |Svetlana Blinova

AbstractInfections by intracellular pathogens often cause insult to host cell DNA, which stimulates responses that ultimately eliminate the damaged cell and hence the microbial niche. p53 is an innate immunity mediator that responds to DNA damage and intracellular infection by transcriptionally activating pathways that arrest the cell cycle, repair DNA, and elicit apoptosis. How pathogens counter p53 are incompletely understood.