David C. Fajgenbaum

Jan 11, 2025 | nature.com | David C. Fajgenbaum

AbstractCastleman disease (CD) is a rare hematologic disorder characterized by pathologic lymph node changes and a range of symptoms due to excessive cytokine production. While uncontrolled infection with human herpesvirus-8 (HHV-8) is responsible for the cytokine storm in a portion of multicentric CD (HHV-8-associated MCD) cases, the etiology of unicentric CD (UCD) and HHV-8-negative/idiopathic MCD (iMCD) is unknown.

Nov 8, 2024 | science.org | Bill Hobbs |Michelle Werner |David C. Fajgenbaum |Erika Gebel Berg

In this webinar, we will dive into the powerful potential of combining protein and RNA measurements within the same tissue section to advance our understanding of complex pathological processes. By integrating spatial transcriptomics with multiplex immunofluorescence, we can uncover detailed information about tissue architecture and how individual cells communicate and interact within their local microenvironment.

Oct 31, 2023 | medscape.com | Eric J. Topol |David C. Fajgenbaum

closePlease confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. This transcript has been edited for clarity. Eric J. Topol, MD: Hello. This is Eric Topol with the Medscape podcast Medicine and the Machine. I'm delighted today to have Dr David Fajgenbaum join me from the University of Pennsylvania, Penn Med.